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Instructions:

This discussion will be completed in two parts and will give you an opportunity to reflect upon this week’s content and to interact with your classmates.

• Part 1 – Post your initial response to the discussion questions by Thursday at 11:59 pm
• Part 2 – Post substantive feedback to two (2) classmates by Sunday at 11:59 pm

Choose one of the root operations that is used in the chapters of the ICD-10-PCS book that are covered this week. What is the root operation and it’s definition? Why did this root operation stand out to you? Please also discuss some of the methods you are using to help to learn the definitions for the root operations since we started this course.

In this assignment, you will conduct A comprehensive analysis of the molecular mechanisms underlying a specific disease or condition of your choice. The purpose of this assignment is to enhance your understanding of advanced pathophysiology concepts and their application to clinical practice, as well as to explore the latest research findings and therapeutic implications related to selected diseases.

The objectives of this assignment include being able to critically analyze the molecular mechanisms underlying the development and progression of a chosen disease or condition, evaluate the role of genetic, environmental, and immunological factors in pathophysiology, and to demonstrate a comprehensive understanding of advanced pathophysiology concepts through the application of molecular mechanisms to clinical manifestations of the selected disease.

 Please choose one disease or condition being learned in the course. Once the disease or condition is chosen, you are to write a three-to-five-page or between 250 or 300 hundreds word.

What is the difference between action research and consulting? How can action research justify its conclusions? Discuss the generalizability of participatory action research.

DUE DATE FEBRUARY 5, 2025

NO MORE THAN 10% PLAGIARISM ALLOWED

FOLLOW INSTRUCTIONS AND REQUIREMENT STRICTLY AS REQUIRED PLEASE

Case 1: Cardiovascular disease is the most common cause of adult morbidity and mortality, accounting for 31% of deaths worldwide. The most common vascular system disorder is hypertension, defined by the American College of Cardiology and the American Heart Association (AHA) as blood pressure >130/80 mm Hg.

A) How do antihypertensive medications interact with determinants of cardiac output and peripheral resistance to reduce blood pressure?

B) What are the most common complications of untreated or undertreated hypertension?

Case 2: The lungs interface with the environment, bringing in atmospheric air during inspiration, and expelling mixed airway and alveolar air during expiration. Gas exchange occurs in the alveoli and depends on lung mechanics as well as blood flow in taking up oxygen and releasing carbon dioxide. The lungs receive all of the blood flow of the right heart, a low-pressure system that perfuses the millions of alveolar capillaries for gas exchange.

A) How does smoking-induced damage to lung tissue lead to emphysema?

B) What is the rationale for using β-agonist drugs in diseases of increased airway resistance?

Describe how the theory of cultural marginality corresponds with caring in the human health experience. Provide an example from practice where you worked with a person who was living on the margins.

Advanced practice nurses must be equipped to critique scholarly literature and discern its value for application to practice. Select one current clinical practice guideline (CPG) related to your PICOT question. If a relevant CPG does not exist, choose a CPG related to another topic. Appraise the CPG using the Rapid Critical Appraisal Questions to Ask of Evidence-Based Guidelines (Melnyk & Fineout-Overholt, 2023, Box 8.4). Summarize your appraisal of the CPG in your own words. 

Include the following sections:

1. Application of Course Knowledge: Answer all questions/criteria with explanations and detail.
   1. Credibility
      1. Who developed the CPG?
      2. Who funded the CPG?
      3. Has the CPG been peer-reviewed?
   2. Comprehensiveness
      1. What method was used to identify, select, or combine evidence?
      2. Was a current, comprehensive literature review included?
      3. Were all important options considered?
      4. Is the strength of evidence noted for each recommendation?
   3. Applicability and generalizability:
      1. Is the intent of use provided?
      2. Are the recommendations clinically relevant?
      3. Are the recommendations relevant to the reader’s population?
      4. Are the recommendations practical and feasible?
      5. Are the recommendations significantly different from current practice?
      6. Are the outcomes measurable using standard care practices?
   4. Include a complete APA reference for the selected CPG.

work attached